{"id":4400,"date":"2020-10-31T13:14:30","date_gmt":"2020-10-31T12:14:30","guid":{"rendered":"https:\/\/encore-expertisecentrum.nl\/?page_id=4400"},"modified":"2025-12-12T16:57:12","modified_gmt":"2025-12-12T15:57:12","slug":"camk2","status":"publish","type":"page","link":"https:\/\/encore-expertisecentrum.nl\/en\/publications\/camk2\/","title":{"rendered":"CAMK2 Syndrome"},"content":{"rendered":"[vc_row][vc_column][vc_tta_accordion][vc_tta_section title=”Publicaties CAMK2 Syndroom” tab_id=”1588325715276-80d12435-d6f0″][vc_column_text]Gauger SJ, et al. (2024) CaMKII\u03b1 hub ligands are unable to reverse known phenotypes in Angelman syndrome mice.\u00a0<\/span><\/strong>Basic Clin Pharmacol Toxicol<\/span>.<\/em> Pubmed<\/a><\/p>\n

Cheung JS, et al. (2024) CAMK2; four genes, one syndrome? Delineation of genotype-phenotype correlations.\u00a0<\/span><\/strong>Curr Opin Neurobiol<\/span>.<\/em> Pubmed<\/a><\/p>\n

Rigter PMF, et.al. (2024) Role of CAMK2D in neurodevelopment and associated conditions.<\/strong> Am J Hum Genet. <\/em>Pubmed<\/a><\/span><\/p>\n

Rigter PMF, de Konink C, van Woerden GM. (2023). Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior.<\/strong> Front Neurosci.<\/em> Jan 6;16:1086994. Pubmed<\/a><\/span><\/p>\n

Rigter PMF, et.al. (2022) Adult Camk2a<\/em> gene reinstatement restores the learning and plasticity deficits of Camk2a<\/em> knockout mice. <\/strong> Pubmed<\/a><\/span><\/p>\n

Dwyer BK, et.al. (2022) Case Report: Developmental Delay and Acute Neuropsychiatric Episodes Associated With a de novo<\/em> Mutation in the CAMK2B<\/em> Gene (c.328G>A p.Glu110Lys) <\/strong>Front Pharmacol.<\/em> 10;13:794008 Pubmed<\/a><\/span><\/p>\n

Onori MP & van Woerden GM. (2021) Role of calcium\/calmodulin-dependent kinase 2 in neurodevelopmental disorders. <\/strong>Brain Res Bull. <\/em>S0361-9230(21)00090-3 Pubmed<\/a><\/span><\/p>\n

Moro A, et.al.<\/em> (2020) CaMKll controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles. <\/strong>PLoS Biol.\u00a0<\/em>Pubmed<\/span><\/a><\/p>\n

Kool MJ, et al.<\/em> (2019) CAMK2-dependent signaling in neurons is essential for survival.<\/strong> J Neurosci<\/em>. 39; 5424\u201339. Pubmed<\/span><\/a><\/p>\n

Vargas JY, et al.<\/em> (2019) The Wnt\/Ca 2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes.<\/em><\/strong> EMBO J<\/em>. Pubmed<\/span><\/a><\/p>\n

Onori MP, et al.<\/em> (2018) The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.<\/strong> Hum Mutat.<\/em> 39; 2008\u201324. Pubmed<\/a><\/span><\/p>\n

K\u00fcry S, et al.<\/em> (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.<\/strong> Am J Hum Genet.<\/em> 101; 768\u201388.\u00a0Pubmed<\/span><\/a><\/p>\n

Kool MJ, et.al. <\/em>(2016) The molecular, temporal and region-specific requirements of the beta isoform of Calcium\/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion.<\/strong> Sci Rep. <\/em>Pubmed<\/span><\/a><\/p>\n

Achterberg KG, et al.<\/em> (2014) Temporal and region-specific requirements of \u03b1CaMKII in spatial and contextual learning.<\/strong> J Neurosci.<\/em> 34; 11180\u20137.\u00a0Pubmed<\/span><\/a><\/p>\n

Woerden G, et.al.<\/em> (2009) betaCaMKll<\/strong> controls the direction of plasticity at parallel fiber-Purkinje cell synapses. <\/strong>Nat Neurosci. <\/em>12(7); 823-5. Pubmed<\/span><\/a><\/p>\n

Hojjati M, et.al.<\/em> (2007) Kinase activity is not required for alphaCaMKll-dependent presynaptic plasticity at CA3-CA1 synapses. <\/strong>Nat Neurosci. <\/em>10(9); 1125-7. Pubmed<\/span><\/a><\/p>\n

Hansel C, et.al.<\/em> (2006) alphaCaMKll is essential for cerebellar LTD and motor learning. <\/strong>Neuron. <\/em>51(6); 835-43. Pubmed<\/span><\/a><\/p>\n

Elgersma Y, et.al. <\/em>(2004) Mouse genetic approaches to investigating calcium\/calmodulin-dependent protein kinase ll function in plasticity and cognition. <\/strong>J Neurosci. <\/em>24(39); 8410-5. Pubmed<\/span><\/a><\/p>\n

Elgersma Y, et.al. <\/em>(2002) Inhibitory autophosphorylation of CaMKll controls PSD association, plasticity and learning. <\/strong>Neuron. <\/em>36(3); 493-505. Pubmed<\/span><\/a>[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_tta_accordion][vc_tta_section title=”Publicaties CAMK2 Syndroom” tab_id=”1588325715276-80d12435-d6f0″][vc_column_text]Gauger SJ, et al. (2024) CaMKII\u03b1 hub ligands are unable to reverse known phenotypes in Angelman syndrome mice.\u00a0Basic Clin Pharmacol Toxicol. Pubmed Cheung JS, et al. (2024) CAMK2; four genes, one syndrome? Delineation of genotype-phenotype correlations.\u00a0Curr Opin Neurobiol. Pubmed Rigter PMF, et.al. (2024) Role of CAMK2D in neurodevelopment and associated conditions. […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":3957,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/pages\/4400"}],"collection":[{"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/comments?post=4400"}],"version-history":[{"count":11,"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/pages\/4400\/revisions"}],"predecessor-version":[{"id":5307,"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/pages\/4400\/revisions\/5307"}],"up":[{"embeddable":true,"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/pages\/3957"}],"wp:attachment":[{"href":"https:\/\/encore-expertisecentrum.nl\/en\/wp-json\/wp\/v2\/media?parent=4400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}