SIMCODA TRIAL
Phase 3 clinical study of the effect of the drug Simvastatin in children with NF1
In this study, designed and conducted by ENCORE, the effect of the drug Simvastatin on cognition was tested in children with NF1. A total of 84 participants took part, who were treated for a year. The study has been completed and the results were published:
Van Der Vaart, T. et al. (2013) Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial. Lancet Neurol 12, 1076–1083. Pubmed